.pa-pharm-lab {
  --lab-blue: var(--pa-color-primary, #2b6f8e);
  --lab-blue-dark: var(--pa-color-primary-hover, #205772);
  --lab-border: var(--pa-color-border, #bdd2df);
  --lab-surface: var(--pa-color-surface, #f5f9fc);
  --lab-raised: var(--pa-color-surface-raised, #fff);
  --lab-text: var(--pa-color-text, #17364b);
  --lab-muted: var(--pa-color-muted, #5f7483);
  color: var(--lab-text);
  font-size: 1rem;
  line-height: 1.55;
}

.pa-pharm-lab *, .pa-pharm-lab *::before, .pa-pharm-lab *::after { box-sizing: border-box; }
.pa-pharm-lab__header { margin-bottom: 1.25rem; }
.pa-pharm-lab__header h2 { margin: 0 0 .4rem; font-size: clamp(1.55rem, 4vw, 2.15rem); color: var(--lab-text); }
.pa-pharm-lab__header p { margin: 0; color: var(--lab-muted); max-width: 75ch; }
.pa-pharm-lab__tabs { display: flex; gap: .45rem; overflow-x: auto; padding: .2rem .1rem .7rem; scrollbar-width: thin; }
.pa-pharm-lab__tab { flex: 0 0 auto; min-height: 44px; padding: .65rem .9rem; border: 1px solid var(--lab-border); border-radius: 999px; background: var(--lab-raised); color: var(--lab-text); font: inherit; font-weight: 700; cursor: pointer; }
.pa-pharm-lab__tab:hover { border-color: var(--lab-blue); background: #eaf5fb; }
.pa-pharm-lab__tab[aria-selected="true"] { color: #fff; background: var(--lab-blue); border-color: var(--lab-blue); }
.pa-pharm-lab__tab:focus-visible, .pa-pharm-lab input:focus-visible, .pa-pharm-lab select:focus-visible, .pa-pharm-lab button:focus-visible { outline: 3px solid var(--pa-color-focus-ring, #8dcced); outline-offset: 2px; }
.pa-pharm-lab__panel[hidden] { display: none !important; }
.pa-pharm-lab__panel { border: 1px solid var(--lab-border); border-radius: var(--pa-radius-lg, 14px); background: var(--lab-surface); padding: clamp(1rem, 3vw, 1.5rem); }
.pa-pharm-lab__panel h3 { margin: 0 0 .35rem; font-size: clamp(1.25rem, 3vw, 1.55rem); }
.pa-pharm-lab__lead { margin: 0 0 1.2rem; color: var(--lab-muted); }
.pa-pharm-lab__grid { display: grid; gap: 1rem; }
.pa-pharm-lab__card { min-width: 0; padding: 1rem; border: 1px solid var(--lab-border); border-radius: 12px; background: var(--lab-raised); }
.pa-pharm-lab__card h4 { margin: 0 0 .8rem; font-size: 1.08rem; }
.pa-pharm-lab__fields { display: grid; gap: .85rem; }
.pa-pharm-lab__field { display: grid; gap: .3rem; }
.pa-pharm-lab label { font-weight: 700; }
.pa-pharm-lab input, .pa-pharm-lab select { width: 100%; min-height: 44px; padding: .62rem .75rem; border: 1px solid #9fb8c8; border-radius: 8px; background: #fff; color: var(--lab-text); font: inherit; }
.pa-pharm-lab input:invalid { border-color: #b22d2d; }
.pa-pharm-lab__button { min-height: 44px; padding: .7rem 1rem; border: 0; border-radius: 8px; background: var(--lab-blue); color: #fff; font: inherit; font-weight: 800; cursor: pointer; }
.pa-pharm-lab__button:hover { background: var(--lab-blue-dark); }
.pa-pharm-lab__metrics { display: grid; grid-template-columns: repeat(2, minmax(0, 1fr)); gap: .65rem; margin-top: 1rem; }
.pa-pharm-lab__metric { padding: .65rem; border-radius: 8px; background: #edf6fb; }
.pa-pharm-lab__metric span { display: block; color: var(--lab-muted); font-size: .82rem; }
.pa-pharm-lab__metric strong { display: block; overflow-wrap: anywhere; font-size: 1.05rem; }
.pa-pharm-lab__chart-wrap { position: relative; min-height: 310px; }
.pa-pharm-lab__chart-wrap canvas { width: 100% !important; height: 310px !important; }
.pa-pharm-lab__axis { display: flex; flex-wrap: wrap; align-items: center; gap: .7rem; margin-top: .8rem; }
.pa-pharm-lab__axis label { font-weight: 500; }
.pa-pharm-lab__axis input { width: auto; min-height: 0; }
.pa-pharm-lab__error { margin: .7rem 0 0; padding: .65rem .8rem; border-left: 4px solid #bd2c2c; background: #fdeaea; color: #7a1e1e; }
.pa-pharm-lab__error:empty { display: none; }
.pa-pharm-lab__formula { overflow-x: auto; padding: .65rem .8rem; border-radius: 8px; background: #eef4f7; font-family: ui-monospace, SFMono-Regular, Menlo, monospace; }
.pa-pharm-lab__examples { margin-top: 1rem; overflow-x: auto; }
.pa-pharm-lab__examples h4 { margin: 0 0 .35rem; }
.pa-pharm-lab__examples-note { margin: 0 0 .65rem; color: var(--lab-muted); font-size: .88rem; }
.pa-pharm-lab__examples table { width: 100%; min-width: 520px; border-collapse: collapse; background: var(--lab-raised); }
.pa-pharm-lab__examples th, .pa-pharm-lab__examples td { padding: .55rem .65rem; border: 1px solid var(--lab-border); text-align: left; vertical-align: middle; }
.pa-pharm-lab__examples th { background: #e7f2f8; }
.pa-pharm-lab__preset { min-height: 38px; padding: .45rem .7rem; border: 1px solid var(--lab-blue); border-radius: 7px; background: #fff; color: var(--lab-blue); font: inherit; font-weight: 700; cursor: pointer; }
.pa-pharm-lab__preset:hover { background: #eaf5fb; }
.pa-pharm-lab__notice { margin-top: 1rem; padding: .75rem .9rem; border-left: 4px solid #d69a3a; background: #fff7e5; color: #654c13; }

@media (min-width: 760px) {
  .pa-pharm-lab__grid { grid-template-columns: minmax(260px, .8fr) minmax(420px, 1.35fr); align-items: start; }
  .pa-pharm-lab__fields--three { grid-template-columns: repeat(3, minmax(0, 1fr)); }
}

@media (max-width: 480px) {
  .pa-pharm-lab__panel, .pa-pharm-lab__card { padding: .85rem; }
  .pa-pharm-lab__metrics { grid-template-columns: 1fr; }
  .pa-pharm-lab__chart-wrap, .pa-pharm-lab__chart-wrap canvas { min-height: 260px; height: 260px !important; }
}

@media (prefers-reduced-motion: reduce) {
  .pa-pharm-lab *, .pa-pharm-lab *::before, .pa-pharm-lab *::after { scroll-behavior: auto !important; transition: none !important; }
}